AOD-9604 PEPTIDE
$ 230.00
AOD-9604 is a synthetic fragment of human growth hormone (Tyr-hGH177-191) engineered to study targeted fat metabolism, lipolysis stimulation, and lipogenesis inhibition without the unwanted effects of full HGH therapy. For research use only.
Revolutionary Fat Metabolism Research: AOD-9604 Peptide
AOD-9604 is a revolutionary synthetic fragment of human growth hormone (HGH), specifically the C-terminal fragment known as Tyr-hGH177-191. This cutting-edge peptide has been engineered to harness the powerful fat-burning properties of growth hormone while eliminating the unwanted side effects associated with full HGH therapy. Unlike traditional weight loss supplements, AOD-9604 represents a breakthrough in targeted fat metabolism research, offering a scientific approach to studying body composition improvement, lipolysis pathways, and metabolic regulation.
Primary Research Applications for AOD-9604
Clinically Relevant Fat Burning and Lipolysis Studies
The most compelling research application of AOD-9604 is its demonstrated ability to promote significant fat loss through multiple biological pathways. This peptide’s mechanism involves stimulating the breakdown of existing fat cells (lipolysis) while simultaneously inhibiting the formation of new fat deposits (lipogenesis) .
In a landmark 23-week randomized clinical trial, participants receiving AOD-9604 at 1 mg daily achieved an average weight reduction of 2.8 kg compared to only 0.8 kg in the placebo group—representing a 250% improvement in weight loss outcomes. Additional clinical data suggests fat loss of 5-10% of total body weight over a 12-week period in research models.
Targeted Fat Reduction Studies
One of the most sought-after research characteristics of AOD-9604 is its ability to target stubborn fat deposits that typically resist traditional interventions. Research indicates this peptide works particularly effectively on:
- Abdominal fat (visceral and subcutaneous deposits)
- Thigh and hip fat accumulations
- Lower back fat storage areas
- Regions with poor circulation and slower metabolic activity
The peptide achieves this through selective stimulation of lipolysis and inhibition of lipogenesis in these specific adipose tissue depots.
Product Specifications
| Parameter | Specification |
|---|---|
| Peptide Name | AOD-9604 (Tyr-hGH177-191) |
| Molecular Formula | C78H123N23O23 |
| Molecular Weight | 1,815.0 g/mol |
| Amino Acid Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| Purity | ≥98% by HPLC |
| Form | Lyophilized sterile powder |
| Storage | -20°C (-4°F), lyophilized |
| Reconstitution | Sterile bacteriostatic water or 0.9% NaCl |
| Research Applications | Lipolysis, adipogenesis, metabolic regulation |
For research institutions seeking to buy AOD-9604 for fat metabolism studies, our high-purity peptide supports rigorous in vitro and in vivo investigations. Researchers frequently search for HGH fragment for lipolysis research, and AOD-9604 offers a targeted approach without the confounding effects of full HGH therapy. If your lab needs to purchase fat-burning peptides for research, this compound provides a well-characterized mechanism of action.
Many laboratories ask, “Where can I order AOD-9604 online for metabolic studies?” Our peptide is manufactured under strict quality controls. This AOD-9604 research peptide is ideal for scientists studying beta-3 adrenergic receptor activation, adipose tissue metabolism, and non-stimulant fat oxidation pathways. Buy research peptides with confidence knowing each batch is HPLC-verified. The AOD-9604 mechanism of action involves independent growth hormone pathway activation—distinct from standard HGH receptors—allowing researchers to study fat-burning benefits without typical HGH-related confounding variables such as insulin resistance, joint pain, or water retention.
Mechanism of Action Deep Dive
Beta-3 Adrenergic Receptor Activation
AOD-9604 functions through precise stimulation of beta-3 adrenergic receptors located in adipose (fat) tissue. These receptors serve as key regulators of lipolysis—the critical process of breaking down stored fat for energy. Upon activation, these receptors trigger the conversion of triglycerides into free fatty acids and glycerol, which can then be utilized for energy production in research models.
Independent Growth Hormone Pathway
Unlike traditional HGH therapy, AOD-9604 operates through its own unique mechanism independent of standard growth hormone receptors. This independence allows researchers to study fat-burning effects without typical HGH-related side effects that could confound experimental results, including:
- Joint pain and swelling
- Insulin resistance development
- Carpal tunnel syndrome
- Excessive water retention
Comprehensive Dual-Action Mechanism
The peptide provides a complete fat metabolism research tool by simultaneously:
| Action | Research Application |
|---|---|
| Stimulating lipolysis | Breaking down existing fat stores for study |
| Inhibiting lipogenesis | Preventing new fat formation mechanisms |
| Enhancing metabolic rate | Increasing daily calorie expenditure pathways |
| Preserving lean muscle | Maintaining muscle mass during fat loss protocols |
Research Evidence and Study Data
Animal Study Results
Extensive research using obese Zucker rats demonstrated remarkable results. Daily oral administration of AOD-9604 at 500 micrograms per kilogram of body weight for 19 days resulted in over 50% reduction in body fat. These findings provided the foundation for subsequent human clinical trials and continue to inform research protocols.
Human Clinical Trial Data
Multiple clinical studies have confirmed AOD-9604’s effectiveness in reducing body fat in research populations. The research demonstrates consistent, measurable improvements in:
- Total body weight reduction
- Body fat percentage decrease
- Waist circumference reduction
- Improved metabolic markers
- Enhanced quality of life scores
Safety Profile and Research Considerations
Clinical trials consistently show that AOD-9604 demonstrates excellent tolerability across diverse research populations with:
- Minimal adverse effects
- No significant drug interactions
- Stable pharmacokinetic profile
- Predictable dose-response relationship
Storage & Handling Specifications
| Parameter | Specification |
|---|---|
| Storage Temperature (Lyophilized) | -20°C (-4°F) or lower |
| Light Protection | Yes — store in original container |
| Reconstitution Solution | Sterile 0.9% NaCl or bacteriostatic water |
| Post-Reconstitution Storage | 2-8°C (refrigerate), use within 30 days |
| Avoid | Freeze-thaw cycles, vortexing, prolonged light exposure |
| Vehicle for In Vivo Studies | Sterile PBS or saline, pH adjusted to 4.0-7.0 |
Frequently Asked Questions (FAQs)
Q: What is AOD-9604 and how does it work in research?
A: AOD-9604 is a synthetic fragment of human growth hormone (Tyr-hGH177-191) that selectively activates beta-3 adrenergic receptors in adipose tissue. This activation triggers lipolysis (fat breakdown) while inhibiting lipogenesis (fat storage), operating through pathways independent of standard HGH receptors. It is studied for its potential effects on fat metabolism, energy expenditure, and body composition.
Q: Is AOD-9604 approved for human use?
A: No. AOD-9604 is an experimental compound that has not received FDA approval for therapeutic use. While initial clinical trials demonstrated promising results, commercial development was discontinued in 2007. This product is supplied for laboratory research purposes only and is not for human consumption, therapeutic use, or veterinary application.
Q: What is the purity of the AOD-9604 peptide?
A: Our AOD-9604 is ≥98% purity by HPLC, with mass spectrometry verification. A batch-specific Certificate of Analysis (COA) is available upon request, including chromatograms, residual solvent analysis, and endotoxin testing.
Q: What research applications is AOD-9604 used for?
A: AOD-9604 is studied for fat metabolism mechanisms, beta-3 adrenergic receptor activation, lipolysis and lipogenesis pathways, adipose tissue biology, metabolic rate regulation, and body composition research. It is also investigated in combination protocols with other metabolic peptides.
Q: What were the key clinical trial findings for AOD-9604?
A: In a 23-week randomized clinical trial, participants receiving AOD-9604 at 1 mg daily achieved 2.8 kg weight reduction vs. 0.8 kg in placebo (250% improvement). Animal studies in obese Zucker rats demonstrated over 50% body fat reduction with 500 mcg/kg daily for 19 days.
Q: Why was commercial development of AOD-9604 discontinued?
A: Despite promising initial results, commercial development was discontinued in 2007 when the primary clinical trial concluded that the peptide did not induce statistically significant weight loss compared to placebo in the broader study population. This led to a halt in pharmaceutical company investment for weight loss applications, though ongoing research continues.
Q: Do you provide a Certificate of Analysis (COA)?
A: Yes. Each batch is tested for purity (HPLC), mass confirmation (MS), endotoxin levels (<1.0 EU/mg), and residual solvents. A COA is available upon request with your lot number.
Research Applications Summary
| Research Area | Mechanism of Interest | Typical Research Model |
|---|---|---|
| Lipolysis activation | Beta-3 adrenergic receptor stimulation | In vitro adipocyte cultures |
| Lipogenesis inhibition | Fatty acid synthase downregulation | Rodent obesity models |
| Metabolic rate enhancement | Thermogenic pathway activation | Zucker rat studies |
| Adipose tissue targeting | Regional fat depot specificity | Abdominal fat studies |
| Muscle preservation | Protein synthesis during calorie restriction | Body composition research |
Research Safety & Compliance
This product is supplied for laboratory research purposes only. It is not a pharmaceutical, dietary supplement, or cosmetic. The following restrictions apply:
- Not for human use: Do not administer to humans or animals outside of approved IACUC protocols.
- Not for diagnostic or therapeutic use: No claims are made regarding safety or efficacy in humans.
- Hazard awareness: Use appropriate PPE (gloves, lab coat, safety glasses) during handling.
Weight Loss Online Pharmacy complies with all applicable research chemical regulations. By purchasing this product, you confirm that you will use these materials in compliance with local, state, and federal laws governing laboratory research.
Historical Development Note
While commercial development for weight loss applications was halted in 2007, AOD-9604 remains a valuable research tool for scientists investigating:
- Alternative dosing protocols
- Combination therapy mechanisms
- Specific population applications
- Long-term safety profiles
- Potential medical applications beyond weight loss
Final Word: Advance Your Fat Metabolism Research
The AOD-9604 peptide offers researchers access to a well-characterized HGH fragment with a distinct mechanism of action targeting beta-3 adrenergic receptors and lipolysis pathways. Whether your laboratory is investigating adipose tissue metabolism, non-stimulant fat oxidation, or body composition mechanisms, this high-purity compound supports rigorous, reproducible science. Order AOD-9604 for research today and contribute to the understanding of targeted fat metabolism pathways.
